Understanding cytotoxicity induction by plumbagin in pancreatic ductal adenocarcinoma using network pharmacology, bioinformatic and in-vitro study

Key Points

• Cytotoxicity induction was evident with plumbagin treatment, affecting cancer cell viability significantly.
• In vitro findings showed over 70% cytotoxic effects at specific concentrations of plumbagin after 48 hours.
• The study employs network pharmacology and bioinformatics to uncover molecular pathways involved in plumbagin's action.
• These results highlight plumbagin's potential as a therapeutic agent, warranting further investigation in clinical settings.