Acid bile salt induces esophageal mucosal barrier dysfunction through miR-146a-5p-KYNU pathway in gastroesophageal reflux disease

Key Points

• Esophageal mucosal barrier dysfunction is induced by acid bile salt exposure, impacting overall digestive health.
• Key evidence shows that alterations in the miR-146a-5p pathway significantly contribute to this dysfunction.
• Analysis of the miR-146a-5p-KYNU pathway identifies critical interactions leading to barrier impairment.
• Understanding these mechanisms may enable the development of targeted therapies for gastroesophageal reflux disease.