Fungal Foe Unveiled: AlphaFold-based 3D structure prediction of Rhizopus delemar 1,3-β-Glucan synthase and virtual screening for the identification of potential inhibitors | Synapse
March 3, 2026Open Access
Fungal Foe Unveiled: AlphaFold-based 3D structure prediction of Rhizopus delemar 1,3-β-Glucan synthase and virtual screening for the identification of potential inhibitors
Key Points
Beta-glucan synthase from Rhizopus delemar shows potential targets for inhibitor development, aiming at fungal control.
3D structure prediction was performed using AlphaFold, providing insights into protein conformation and function.
Virtual screening led to the identification of novel inhibitors, enhancing antifungal drug discovery efforts.
Understanding the enzyme's structure may inform better antifungal treatments and drug design paths for clinical application.