Artificial sweeteners and male infertility: Network toxicology and experimental evidence reveal FGFR1 as the critical target

Key Points

• Artificial sweeteners may negatively affect male fertility through toxicological pathways.
• Network toxicology findings indicate FGFR1 as a significant biological target impacted by artificial sweeteners.
• Assessment utilized in vitro experiments to establish the relationship between sweeteners and male infertility.
• Implications suggest the need for further studies to thoroughly understand the impact of artificial sweeteners on reproductive health.