Ruminococcaceae promotes the NLRP3/ASC/Caspase-1 axis–mediated pyroptotic signaling in papillary thyroid carcinoma by upregulating RBM15 to increase the N6-methyladenosine methylation modulation of NLRP3 | Synapse
March 3, 2026
Ruminococcaceae promotes the NLRP3/ASC/Caspase-1 axis–mediated pyroptotic signaling in papillary thyroid carcinoma by upregulating RBM15 to increase the N6-methyladenosine methylation modulation of NLRP3
Key Points
Findings show upregulation of RBM15, which enhances pyroptotic signaling through the NLRP3 axis.
The study identifies significant modulation of N6-methyladenosine methylation impacting NLRP3 function in cancer cells.
Assessment of the tumor microenvironment reveals the influence of Ruminococcaceae on apoptotic pathways during tumor progression.
The implications suggest potential therapeutic targets for managing papillary thyroid carcinoma development.