ERK-dependent astrocytic PAI-1 induction by influenza A virus disrupts the neurochemical balance of the PAI-1/tPA axis

Key Points

• Disruption of the neurochemical balance occurs through PAI-1 induction.
• Key evidence indicates that influenza A virus affects the PAI-1/tPA axis heavily.
• The study employs an observational analysis to assess the impact on astrocytic activity.
• Findings highlight the need for further exploration of viral impacts on brain chemistry.