Effects of a standardized extract of Asparagus officinalis stem on microglial functions and LPS-administered mice behaviors

A standardized extract of Asparagus officinalis stem (EAS) has shown anti-inflammatory effects. Many central nervous system (CNS) disorders are associated with neuroinflammation. Microglia play an important role in the immune response in the CNS. However, no therapeutic agents targeting microglial regulation have been successfully translated into clinical practice. Therefore, we investigated the effects of EAS on microglial function and CNS health. EAS suppressed the expression of interleukin 1β (Il1b) and inducible nitric oxide synthase (inos) in lipopolysaccharide (LPS)-stimulated microglia while promoting the expression of heat shock protein 70 (Hsp70) and vascular endothelial growth factor a (Vegfa). The EAS-induced suppression of Il1b and inos was mediated by the inhibition of NF-κB activation, whereas the upregulation of Hsp70 and Vegfa was associated with the activation of heat shock transcription factor 1. Additionally, EAS alleviated depression-like behaviors in LPS-administered mice. Our findings suggest the potential therapeutic benefits of EAS for CNS disorders.