The discovery of multiregional neurotoxicity-associated metabolic alterations induced by Aconiti Lateralis Radix Praeparata in brain of rat using LC-MS metabolomics
Key Points
Metabolic alterations indicate significant neurotoxic effects in the rat brain from Aconiti Lateralis Radix Praeparata exposure.
Using LC-MS metabolomics, the analysis highlighted multiple affected metabolic pathways and their implications.
Observed neurotoxicity revealed distinct patterns of metabolites influenced by Aconiti Lateralis Radix Praeparata in the brain.
Findings suggest the need for further investigation on neurotoxic potential and metabolic disruptions caused by this herbal ingredient.
The discovery of multiregional neurotoxicity-associated metabolic alterations induced by Aconiti Lateralis Radix Praeparata in brain of rat using LC-MS metabolomics | Synapse