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A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration | Synapse
March 3, 2026
Open Access
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration
EI
Ernest Iu
AB
Alexander Bogatch
WD
Wenjun Deng
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Key Points
Cell migration enhances with proper actin architecture remodeling in lamellipodia.
Key evidence shows a significant correlation between TRPV4 activation and calcium influx in migrating cells.
Analysis of calcium signaling pathways highlights the role of TRPV4 in regulating actin dynamics.
Finding supports potential therapeutic strategies targeting cell migration in various diseases.
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Iu et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76818badf0bb9e87e394a
https://doi.org/https://doi.org/10.1016/j.cub.2026.01.024