What question did this study set out to answer?

The study aims to design and evaluate new compounds for selective cytotoxicity against HeLa cells.

March 5, 2026Beilstein Journal of Organic Chemistry0 citationsOpen Access

Design, synthesis and biological evaluation of 2,5-diaryloxazolo4,5- d pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells

DHDiana HodynaInstitute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar AOAgnieszka B. OlejniczakInstitute for Medical Biology MDMarta Denel‐BobrowskaInstitute for Medical Biology

Key Points

The study aims to design and evaluate new compounds for selective cytotoxicity against HeLa cells.
Designed and synthesized nine novel compounds.
Characterized compounds using NMR and mass spectrometry techniques.
Assessed anticancer activity against HeLa and non-cancer cell lines.
Compounds 1, 3, and 9 showed high cytotoxicity with IC50 values of 6.13, 13.99, and 49.92 μM respectively.
Compounds 1, 7, and 9 displayed selectivity towards cancer cell lines.
Compound 9 emerged as a promising candidate for further development.

Abstract

Nine novel functionalized 2,5-diaryloxazolo4,5- d pyrimidin-7-ylamines were designed, synthesized and characterized using 1 H, 13 C NMR, IR spectroscopy, elemental analysis, and liquid chromatography–mass spectrometry . Their anticancer activity was assessed against human cancer cell as well as non-cancer cell lines. Three compounds, 1 , 3 , and 9 , were the most cytotoxic to HeLa cells (IC 50 = 6.13 ± 1.95, 13.99 ± 1.80 and 49.92 ± 3.98 μM, respectively). However, only compounds 1 , 7 , and 9 were selective against the tested lines. Compound 9 can be classified as the most attractive and promising candidate for further development against cervical adenocarcinoma.

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Cite This Study

Hodyna et al. (Tue,) studied this question.

synapsesocial.com/papers/69a91dd2d6127c7a504c1109 https://doi.org/https://doi.org/10.3762/bjoc.22.27

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