A Novel 9-Day Desensitization Protocol for Elexacaftor/Tezacaftor/Ivacaftor in a Child with Cystic Fibrosis

Key Points

• This case report aims to outline a desensitization protocol for a child experiencing hypersensitivity to Trikafta.
• Case report of a child with cystic fibrosis and hypersensitivity to Trikafta.
• Patient observed for hypersensitivity reactions following therapy initiation.
• A desensitization plan was implemented over nine days.
• The patient experienced a rash and shortness of breath after eight days on the therapy.
• Hypersensitivity was confirmed when symptoms recurred after re-dosing.
• The protocol's potential effectiveness is suggested, though further studies are needed.