Review of: Benchmarking circRNA Detection Tools from Long-Read Sequencing Using Data-Driven and Flexible Simulation Framework. Round#1/Reviewer#2

Key Points

• The aim is to evaluate various detection tools for circRNA from long-read sequencing data.
• Benchmarking of circRNA detection tools was conducted.
• A data-driven simulation framework was utilized for testing.
• Analysis was performed on the performance metrics of each tool.
• Identified strengths and weaknesses of different circRNA detection tools.
• Proposed enhancements for tool performance based on simulation outcomes.