Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes.

Key Points

• This research evaluates the implications of mosaic activation of the hsp70l promoter for transgene functionality.
• Assessment of hsp70l promoter activation in zebrafish
• Comparison of cell-autonomous and non-cell-autonomous gene functions
• Analysis of controls for interpreting transgene activity
• Mosaic activation provides a beneficial tool for temporal gene activation
• Caution is necessary when associating transgene behavior with cell-autonomy
• Certain contexts show clearer functional insights from the transgene