TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model

Key Points

• The research aims to explore how mental stress affects psoriasis severity through immune system changes.
• Used a mouse model to simulate psoriasis and mental stress
• Evaluated inflammatory markers and immune responses
• Analyzed TLR9/MyD88/NF-κB signaling pathways
• Mental stress significantly increased inflammation in psoriasis models
• Immunological changes were linked to TLR9/MyD88/NF-κB signaling activation
• Study highlights the connection between stress and psoriasis worsening