Larger left atrial volume, LAA orifice size, and LAA depth strongly correlate with thrombus presence or stroke history in AF patients, complementing CHA2DS2-VASc.
CFD-based hemodynamic and morphometric parameters, such as LA volume and LAA orifice size, correlate strongly with thrombus presence or stroke history in AF patients, potentially complementing clinical risk scores.
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PURPOSE: Stroke is a leading cause of death worldwide, with atrial fibrillation (AF) contributing to up to a third of ischemic strokes. Current clinical risk scores, like the CHA METHODS: We analyzed 40 patient-specific LA models reconstructed from computed tomography, incorporating a physiologically realistic atrial wall motion derived from an AF motion model. High-fidelity CFD simulations were performed under pathological conditions to compute hemodynamic and morphometric parameters, which were then statistically correlated with thrombus presence or stroke history. RESULTS: Univariate logistic analysis showed that LA volume, left atrial appendage (LAA) orifice size, and LAA depth correlated strongly with thrombus presence or stroke history (Pseudo CONCLUSION: These results demonstrate that CFD-based and morphometric parameters can complement the CHA
Kjeldsberg et al. (Fri,) reported a other. Larger left atrial volume, LAA orifice size, and LAA depth strongly correlate with thrombus presence or stroke history in AF patients, complementing CHA2DS2-VASc.