What question did this study set out to answer?

The research aims to investigate the effects of 40 Hz visual flicker on cognitive impairments caused by anesthesia and surgery in elderly mice.

March 10, 2026Open Access

Intraoperative 40 Hz Visual Light Flicker Attenuates Anesthesia/Surgery‐Induced Cognitive Impairments in Elderly Mice With Enhanced Cortical‐Hippocampal Coherence

Key Points

The research aims to investigate the effects of 40 Hz visual flicker on cognitive impairments caused by anesthesia and surgery in elderly mice.
Utilized a mouse model of anesthesia and surgery.
Applied 40 Hz light flicker during the surgical procedure.
Measured cognitive performance and cortical-hippocampal coherence post-surgery.
40 Hz flicker significantly improved cognitive function compared to controls.
Enhanced gamma coherence between the visual cortex and hippocampus was observed.
Indications suggest this intervention helps in preventing post-operative cognitive decline (PND).

Abstract

Our results suggest that 40 Hz flicker mitigates anesthesia/surgery-induced cognitive deficits, potentially through modulating gamma coherence between the visual cortex and hippocampus. These findings provide insights into PND prevention and the neural mechanisms underlying 40 Hz-induced cognitive benefits.

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Cite This Study

Jiang et al. (Sun,) studied this question.

synapsesocial.com/papers/69af958570916d39fea4d2be https://doi.org/https://doi.org/10.1002/cns.70809

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