What question did this study set out to answer?

This research aims to analyze the transcriptomic changes in Kupffer cells during liver inflammation over time in a mouse model of Chronic Hepatitis B.

March 13, 2026Open Access

Transcriptomic landscape of liver inflammation across time in AAV-HBV mice models

Key Points

This research aims to analyze the transcriptomic changes in Kupffer cells during liver inflammation over time in a mouse model of Chronic Hepatitis B.
Utilized 10x single-cell RNA sequencing (scRNA-seq) to profile Kupffer cells
Examined transcriptomic data across different time points in the liver inflammation model
Focused on mice models with Chronic Hepatitis B infection.
Characterized the dynamic transcriptomic landscape of Kupffer cells during liver inflammation
Identified specific gene expression patterns related to the inflammatory response
Demonstrated temporal changes in Kupffer cell activity associated with disease progression.

Abstract

In this work, we use 10x scRNA-seq to describe the transcriptomic landscape of Kupffer cells across time in mice model with Chronic Hepatitis B.

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石静琦 (Thu,) studied this question.

synapsesocial.com/papers/69b3aba202a1e69014ccca53 https://doi.org/https://doi.org/10.26036/cnp0006059