Divergent Assembly of Fused Polycyclic Scaffolds from Iodotriazole-Tethered Benzaldehydes

Key Points

• This research aims to explore the chemical potential of iodotriazole-tethered benzaldehydes in synthesizing various fused heterocyclic structures.
• Synthesis of 5-iodo-1,2,3-triazoles with formyl groups via ortho-phenylene linkers
• Synthetic pathways evaluated for versatility in creating heterocyclic compounds
• Characterization of reaction products to assess fused scaffold formation
• Demonstrated high reactivity of the aldehyde in nucleophilic attacks
• Produced a variety of fused heterocycles with diverse functional groups
• Outlined conditions that optimize scaffold assembly