Reaction Profiling of Visible Light-Mediated 2+1 Dearomatization vs Alkylation of Electron-Rich Arenes with Aryldiazoacetates: Real-Time NMR Monitoring, Kinetics, and Computational Analysis

Key Points

• The aim is to explore the mechanisms of dearomatization and alkylation reactions involving electron-rich arenes and aryldiazoacetates.
• Conducted real-time NMR monitoring of reactions
• Analyzed kinetics of dearomatization and alkylation
• Utilized computational analysis to support findings
• Tuned electron density on arenes to assess regioselectivity
• Norcaradienes were synthesized regioselectively and diastereoselectively
• Strategic tuning of electron density significantly affected reaction outcomes
• Real-time monitoring provided insights into reaction kinetics
• Computational models corroborated experimental data