March 13, 2026

Two-Stage Prepectoral Breast Reconstruction with and without Acellular Dermal Matrix: A Cluster-Randomized Noninferiority Trial.

Q: What does this research mean for the field?

Two-stage prepectoral breast reconstruction with acellular dermal matrix (ADM) is noninferior to reconstruction without ADM regarding major 90-day postoperative complications. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Key Points

The study aims to compare two-stage prepectoral breast reconstruction with and without acellular dermal matrix (ADM) regarding postoperative complications and patient outcomes.
Cluster-randomized trial design
Participants were assigned to two groups: with ADM and without ADM
Assessment of major and minor postoperative complications
Evaluation of patient-reported outcomes and pain levels
Reconstruction with ADM was noninferior to without ADM for major 90-day postoperative complications
Minor complications and patient-reported outcomes were comparable between groups
The routine use of ADM is supported as a safe option for breast reconstruction

Abstract

Two-stage prepectoral breast reconstruction with ADM was noninferior to reconstruction without ADM regarding major 90-day postoperative complications, with comparable minor complications, patient-reported outcomes, and pain. These findings support the routine use of ADM as a safe option. Long-term follow-up comparing relevant clinical outcomes is needed to clarify the benefits of ADM.Trial Registration: Clinicaltrials.gov NCT05316324.

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Cite This Study

Nelson et al. (Wed,) studied this question.

synapsesocial.com/papers/69b3ad1302a1e69014ccf52c https://doi.org/https://doi.org/10.1097/prs.0000000000013019

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