What question did this study set out to answer?

To explore the impact of long-term chemotherapy on cardiovascular health in breast cancer survivors.

March 15, 2026Open Access

Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long‐Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab‐Based Chemotherapy

Key Points

To explore the impact of long-term chemotherapy on cardiovascular health in breast cancer survivors.
Examined sympathetic neural activity
Assessed vascular function
Evaluated exercise capacity
Identified sympathetic overdrive in survivors
Documented vascular dysfunction
Observed exercise intolerance

Abstract

Our findings demonstrate that long-term survivors of breast cancer exhibit sympathetic overdrive, vascular dysfunction, and exercise intolerance, which may contribute to increased cardiovascular disease risk in this population.

Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long‐Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab‐Based Chemotherapy

Key Points

Abstract

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