Arterial Catheter-Associated Proximal Ischemic Injury in Critically Ill Children: Evidence of Endothelial Dysfunction and Immune Dysregulation

Key Points

• The study aims to explore the pathways of immune dysregulation and endothelial dysfunction in critically ill children with arterial catheter-associated ischemic injury.
• Analyzed a small pediatric cohort experiencing arterial catheter-associated proximal ischemic injury (ACAPII)
• Identified pathways of immune dysregulation and endothelial dysfunction associated with ACAPII
• Found evidence of endothelial dysfunction and immune dysregulation in the cohort
• Indicated a potential window for treatment before the onset of ACAPII