Fluorine-containing FDA-approved small-molecule drugs in 2025: significance, synthetic insights, and therapeutic applications

Key Points

• The research aims to explore the significance and applications of fluorine-containing small-molecule drugs approved by the FDA by 2025.
• Analyzed the incorporation of fluorine into small-molecule drugs.
• Reviewed therapeutic applications and implications for drug design.
• Investigated synthetic strategies for fluorine-containing compounds.
• Fluorine enhances the metabolic stability and lipophilicity of drugs.
• Improved target interactions observed with fluorine incorporation.
• The pharmacokinetic profile is significantly affected by fluorine in drug design.