What question did this study set out to answer?

The study aims to explore how MaiMenDong Decoction reduces inflammation and immune dysfunction in primary Sjögren’s syndrome.

March 16, 2026

MaiMenDong Decoction Alleviates Primary Sjögren’s Syndrome by Dual Suppression of Inflammation and Immune Dysregulation: A Synergy of Network Pharmacology and NOD/Ltj Mouse Studies

Key Points

The study aims to explore how MaiMenDong Decoction reduces inflammation and immune dysfunction in primary Sjögren’s syndrome.
Utilized network pharmacology to identify key pathways
Investigated TLR4/MyD88/NF-κB pathway activation
Examined Treg cell-mediated immune restoration in NOD/Ltj mice
Demonstrated reduced activation of TLR4/MyD88/NF-κB pathway
Lowered release of pro-inflammatory cytokines
Enhanced function of AQP5-dependent salivary secretion

Abstract

MMDT exerts its therapeutic effects on pSS through multi-target inhibition of TLR4/MyD88/NF-κB pathway activation, thereby reducing the release of pro-inflammatory cytokines, promoting Treg cell-mediated restoration of immune homeostasis, and recovering AQP5- dependent salivary secretion function. These findings collectively provide novel mechanistic evidence for the application of Traditional Chinese Medicine (TCM) in the treatment of pSS. .

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MaiMenDong Decoction Alleviates Primary Sjögren’s Syndrome by Dual Suppression of Inflammation and Immune Dysregulation: A Synergy of Network Pharmacology and NOD/Ltj Mouse Studies

Key Points

Abstract

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