What question did this study set out to answer?

To evaluate recurrent nonhyperinsulinemic hypoglycemia in late-preterm infants and its management.

March 16, 2026Open Access

Recurrent Hypoglycemia in Two Late‐Preterm Infants With Transitional Disorder of Glucose Mobilization—Case Series

Key Points

To evaluate recurrent nonhyperinsulinemic hypoglycemia in late-preterm infants and its management.
Case series of two late-preterm infants with recurrent hypoglycemia.
Assessment of glucose mobilization impairment.
Administration of diazoxide for treatment.
Both infants exhibited recurrent hypoglycemia not attributed to hyperinsulinism.
Inadequate glucagon response suggested immature hepatic enzymes.
Negative genetic testing ruled out glycogen storage disorders.

Abstract

ABSTRACT Great emphasis is placed upon addressing hyperinsulinism in at‐risk infants with recurrent hypoglycemia. We report two preterm infants with recurrent nonhyperinsulinemic hypoglycemia due to transient impairment of glucose mobilization, warranting diazoxide use. Inadequate response to glucagon stimulation test indicates hepatic enzyme immaturity especially with negative genetic testing for glycogen storage disorders.

Recurrent Hypoglycemia in Two Late‐Preterm Infants With Transitional Disorder of Glucose Mobilization—Case Series

Key Points

Abstract

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