Comment on “Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions” by D. Patra and A. Saha, Org. Chem. Front. , 2023, 10 , 1686 | Synapse
March 19, 2026Open Access
Comment on “Dithiocarbamate-mediated thioamidation of arylglyoxylic acids by decarboxylative–decarbonylative C–C bond formation reactions” by D. Patra and A. Saha, Org. Chem. Front. , 2023, 10 , 1686
Key Points
To assess the validity of the proposed mechanism for the thioamidation of arylglyoxylic acids.
Analysis of reaction yields
Use of 13C labeling to track carbon
Computational studies to evaluate the mechanism
The reaction yields are only 5%, indicating inefficiency.
The proposed mechanism was shown to be incorrect based on computational analysis.
Abstract
The purported reaction occurs only in trace amounts (5% yield). 13 C labelling and computational studies show that the suggested mechanism is incorrect.