Surgical resection and adjuvant chemoradiation for a rare mediastinal extraskeletal osteosarcoma compressing the right atrium achieved clinical stability at 11 months despite lung metastases.
This case highlights the diagnostic and therapeutic challenges of rare mediastinal extraskeletal osteosarcoma with cardiac involvement, emphasizing the utility of multimodality imaging.
Absolute Event Rate: 0% vs 0%
Mediastinal extraskeletal osteosarcoma (ESOS) with cardiac involvement is extremely rare and aggressive. The authors describe a 56-year-old male individual presenting with chest tightness and dyspnea. Imaging revealed a large pericardial mass compressing the right atrium. Surgical resection was performed, and histopathology findings confirmed high-grade ESOS. The patient underwent adjuvant radiation therapy and chemotherapy. At 6 months, pulmonary metastases were detected, prompting treatment adjustment. At 11-month follow-up, the patient remained clinically stable. This case underscores the utility of multimodality imaging and the diagnostic and therapeutic challenges of this rare malignancy. Keywords: Cardiac, Oncology © RSNA, 2026
Huang et al. (Thu,) reported a other. Surgical resection and adjuvant chemoradiation for a rare mediastinal extraskeletal osteosarcoma compressing the right atrium achieved clinical stability at 11 months despite lung metastases.