Bisphenol A Decreases Peripheral Insulin Sensitivity in Normal Weight Adults: A Double-Blind Randomized Controlled Trial | Synapse
March 25, 2026Open Access
Bisphenol A Decreases Peripheral Insulin Sensitivity in Normal Weight Adults: A Double-Blind Randomized Controlled Trial
Key Points
To investigate the effects of bisphenol A (BPA) on peripheral insulin sensitivity in humans.
Conducted a double-blind randomized controlled trial
Administered BPA to normal weight adults over 5 days
Measured changes in insulin sensitivity
BPA administration decreased peripheral insulin sensitivity after 5 days
This is the first experimental evidence in humans regarding BPA's impact on insulin sensitivity
Abstract
BPA administration decreased peripheral insulin sensitivity after 5 days. These data provide the first experimental evidence in humans that BPA administration may reduce insulin sensitivity.