Nonenzymatic Carbamoylation and Phosphorylation via Urea Nitrosylation under Mild Aqueous Conditions

Key Points

• The aim is to explore nonenzymatic carbamoylation and phosphorylation processes using urea nitrosylation.
• Utilized copper sulfide to promote urea nitrosylation under mild aqueous conditions.
• Investigated a range of reactions to assess the formation of carbamoyl phosphate.
• Successfully formed carbamoyl phosphate from urea and phosphate.
• Showed that the reaction pathway is significant for prebiotically important processes.