September 27, 2011Open Access

Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy

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Abstract

Collectively, these studies demonstrate that the vitamin D-VDR signaling system possesses direct, antihypertrophic activity in the heart. This appears to involve, at least in part, suppression of the prohypertrophic calcineurin/NFAT/MCIP1 pathway. These studies identify a potential mechanism to account for the reported beneficial effects of vitamin D in the cardiovascular system.

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Chen et al. (Tue,) studied this question.

synapsesocial.com/papers/69c3e5c48e4954c5d5d0391e https://doi.org/https://doi.org/10.1161/circulationaha.111.032680

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1Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy2000 · 202 citations
2Blood Pressure is Lowered by Vitamin D (Alphacalcidol) during Long‐Term Treatment of Patients with Intermittent Hypercalcaemia1987 · 54 citations
3Transcriptional Regulation During Cardiac Growth and Development1993 · 368 citations
4Independent Signals Control Expression of the Calcineurin Inhibitory Proteins MCIP1 and MCIP2 in Striated Muscles2000 · 356 citations
5Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism1999 · 302 citations

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