What question did this study set out to answer?

To investigate the role of SOX5 overexpression in Schwann cells and its effect on peripheral nerve regeneration.

March 26, 2026Journal of the Peripheral Nervous System1 citations

SOX5 Overexpression in Schwann Cell Combined With Chitosan‐Based Conduit Promotes Peripheral Nerve Regeneration

BMBo Ma FZFengshi Zhang JSJunyu SuShenzhen University

Key Points

To investigate the role of SOX5 overexpression in Schwann cells and its effect on peripheral nerve regeneration.
Utilized lentivirus for SOX5 overexpression in Schwann cells
Integrated overexpressed Schwann cells with chitosan-based conduits
Evaluated structural and functional outcomes of nerve regeneration
SOX5 overexpression shifted Schwann cells towards a repair phenotype
Chitosan conduits effectively supported nerve regeneration
Combined approach resulted in improved structural and functional recovery of nerves

Abstract

Lentivirus-mediated SOX5 overexpression drives Schwann cells toward a repair phenotype and, when integrated with a small-gap chitosan-based conduit, effectively promotes structural and functional nerve regeneration.

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