What question did this study set out to answer?

Explore the role of autophagy-associated FIP200 in protecting renal tubules from apoptosis during ischemia-reperfusion injury.

March 28, 2026Open Access

WCN26-4071 Autophagy-associated FIP200 protects renal tubules against apoptosis following renal ischemia-reperfusion injury

Key Points

Explore the role of autophagy-associated FIP200 in protecting renal tubules from apoptosis during ischemia-reperfusion injury.
Analyzed biomarker responses after renal ischemia-reperfusion injury
Measured levels of urinary TIMP-2 and IGFBP7 as indicators of acute kidney injury (AKI)
Used AUROC analysis to evaluate biomarker predictive performance
TIMP-2 and IGFBP7 showed high sensitivity (88.4%) and specificity (88.7%) for AKI detection
Biomarker elevation occurred 24-48 hours before serum creatinine levels increased
Identified women at high risk for postpartum renal acute kidney injury with a product level of 0.938 ng/mL

Abstract

10 3, TIMP-2*IGFBP7 achieved an AUROC = 0. 904 (95 % CI 0. 845-0. 963), sensitivity 88. 4 %, specificity 88. 7 %, PPV 67. 9 %, NPV 96. 6 %. Biomarker elevation preceded serum creatinine rise by 24-48 h. Three patients required renal replacement therapy; one death occurred due to multiorgan failure. Conclusion: Urinary TIMP-2 and IGFBP7 provide sensitive and specific early detection of AKI in preeclamptic pregnancies. The TIMP-2*IGFBP7 product 0. 938 ng/mL 2 /10 3 identifies women at high risk for PRAKI well before conventional markers rise, supporting early nephroprotective intervention. I have no potential conflict of interest to disclose. I did not use generative AI and AI-assisted technologies in the writing process.

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Cite This Study

Li et al. (Wed,) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e06ad https://doi.org/https://doi.org/10.1016/j.ekir.2026.103889

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