What question did this study set out to answer?

This research aims to identify modifiable determinants contributing to rapid kidney function decline in adults with chronic kidney disease (CKD).

March 28, 2026Open Access

Wcn26-5613 Burden and Modifiable Determinants of Rapid Kidney Function Decline Among Adults With CKD in Northern Tanzania

Key Result

SGLT2 inhibition reverses abnormal renal oxygenation in obesity and type 2 diabetes, supporting multiparametric kidney MRI as a non-invasive tool to track therapeutic response.

Key Points

This research aims to identify modifiable determinants contributing to rapid kidney function decline in adults with chronic kidney disease (CKD).
Utilized multiparametric MRI to assess kidney function and structure.
Evaluated hemodynamics and oxygenation changes associated with obesity and type 2 diabetes.
Analyzed the effects of SGLT2 inhibition on renal performance.
Found that MRI effectively detects changes in kidney oxygenation and structure in early diabetic kidney disease.
SGLT2 inhibition was associated with improvements in renal oxygenation.
Support for MRI as a non-invasive method to monitor kidney health and therapy response.

Structured PICO

Population

Adults (≥18 years) with CKD stages 3–5 attending the KCMC renal clinic

Outcome

Rapid CKD progression (annual eGFR decline > 5 mL/min/1.73 m2)surrogate

Low serum albumin, hyponatremia, and elevated systolic blood pressure are strong, modifiable predictors of rapid kidney function decline in adults with CKD in Northern Tanzania.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Conclusion: Multiparametric kidney MRI sensitively captures stagedependent hemodynamics, structural change, and oxygenation in obesity and T2D.SGLT2 inhibition demonstrates reversal of abnormal renal oxygenation, evidenced by favorable changes in medullary FSOC.These findings support multiparametric MRI as a non-invasive biomarker suite to track progression and therapeutic response in early diabetic kidney disease.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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Cite This Study

Akrabi et al. (Wed,) reported a other. SGLT2 inhibition reverses abnormal renal oxygenation in obesity and type 2 diabetes, supporting multiparametric kidney MRI as a non-invasive tool to track therapeutic response.

synapsesocial.com/papers/69c770418bbfbc51511e07aa https://doi.org/https://doi.org/10.1016/j.ekir.2026.104355

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