Gilbert’s Syndrome (GS) is a genetic disorder marked by reduced bilirubin conjugation due to enzymatic deficiency, resulting in unconjugated hyperbilirubinemia. While GS is typically asymptomatic, this report presents a rare case of recurrent aphthous stomatitis (RAS) as a possible oral manifestation. A 21-year-old male with GS experienced multiple episodes of painful oral ulcers. Conventional therapy using tetracycline mouth rinse provided limited relief. A novel approach employing self- formulated 2% tetracycline mucoadhesive gel demonstrated superior symptomatic improvement. Clinical outcomes were objectively assessed using fractal analysis, which showed greater remission rates with gel therapy compared to rinse.
Murugan et al. (Thu,) studied this question.
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