Humoral responses against high-density lipoprotein are linked to unfavorable lipid and proteomic signatures in primary Sjögren disease–a multi-platform approach

Key Points

• To explore the relationship between humoral responses against HDL particles and lipid profiles in primary Sjögren disease.
• Multi-platform approach to analyze humoral responses and lipid profiles.
• Assessment of lipoprotein composition in Sjögren disease patients.
• Clinical correlates evaluated alongside humoral responses.
• Anti-HDL responses correlated with unfavorable lipid signatures.
• Distinct trajectories observed for functional and clinical correlates.
• Findings suggest a link between autoimmunity and cardiovascular disease risk.