The Clinical Role of miR ‐744‐5p in Osteoarthritis and Its Regulation of Chondrocyte Inflammation Through the Modulation of Thrombospondin‐2 ( THBS2 ) Expression

Key Points

• This research examines the role of miR-744-5p in osteoarthritis and its impact on chondrocyte inflammation through THBS2 regulation.
• Analyzed miR-744-5p expression levels in osteoarthritis samples
• Conducted experiments to assess its regulatory effect on THBS2
• Evaluated inflammation response in chondrocytes upon miR-744-5p modulation.
• miR-744-5p is significantly downregulated in osteoarthritis
• Modulation of miR-744-5p leads to decreased THBS2 expression
• Inhibition of THBS2 reduces inflammation in chondrocytes.