Proteome Profiles of Hypercholesterolemic Patients with and Without FH Treated with a PCSK9 Inhibitor: A Comparison of Depleted and Nondepleted Samples in a Pilot Study

Key Points

• This research examines the impact of PCSK9 inhibitors on the proteome of individuals with and without familial hypercholesterolemia (FH).
• Comparative analysis of proteome profiles between HeFH and non-FH patients.
• Assessment of responses to PCSK9 inhibitor treatment.
• Utilization of depleted and nondepleted plasma samples.
• Identified differences in proteomes between individuals with HeFH and those without FH.
• PCSK9i treatment significantly affects the plasma proteome in both groups.