Orodispersible tablets (ODTs) represent a significant advancement in pharmaceutical technology, offering rapid disintegration and dissolution in the oral cavity without requiring water intake. This comprehensive review examines the application of natural superdisintegrants in ODT formulations, emphasizing their mechanism of action, advantages over synthetic alternatives, and practical applications in modern pharmaceutical science. Natural superdisintegrants such as fenugreek seed mucilage, Plantago ovata (psyllium) husk, guar gum, and other plant-derived polymers have demonstrated comparable or superior disintegration properties to synthetic agents while offering biocompatibility, biodegradability, and cost-effectiveness.1,2 This paper provides an in-depth analysis of formulation techniques, optimization strategies using Quality by Design (QbD) approaches, evaluation parameters, and therapeutic applications of ODTs incorporating natural superdisintegrants. Special emphasis is placed on BCS Class II drugs where enhanced bioavailability through rapid disintegration can significantly improve therapeutic outcomes. Current regulatory perspectives, challenges in scale-up manufacturing, and future directions for natural superdisintegrant research are also discussed. The review synthesizes recent literature and clinical evidence to provide a comprehensive understanding of ODT technology for pharmaceutical researchers, formulators, and academic professionals.
Jagtap* et al. (Mon,) studied this question.