Subclinical hypothyroidism and height loss in relation to the status of thyroid cysts: a prospective study

Background: Despite numerous recent studies linking height loss to the risk of cardiovascular disease, the underlying biological mechanisms are poorly understood. Subclinical hypothyroidism (SCH) has been positively associated with height loss in individuals with low-normal range free thyroxine (FT4) levels. This association may stem from impaired endothelial repair caused by an inadequate response to the increased thyroid hormone demand. Recent evidence has highlighted the clinical significance of thyroid cysts in terms of their endothelial-related activity. Consequently, it is plausible that thyroid cysts influence the relationship between SCH and height loss.