Investigating the Role of TNFSF12 in Thyroid Cancer Progression via Single‐Cell RNA Sequencing and Integrated Multiomics Analyses

Key Points

• The aim is to examine how TNFSF12 influences thyroid cancer progression through comprehensive analyses.
• Utilized single-cell RNA sequencing to identify cellular dynamics in thyroid cancer.
• Conducted integrated multiomics analyses to explore the regulatory networks.
• Analyzed the expression patterns of TNFSF12 in different contexts.
• Identified a myeloid-centered regulatory network involved in thyroid cancer.
• Demonstrated TNFSF12 acts as a context-dependent oncogene.
• Provided insights for potential targeted therapy and immunotherapeutic strategies.