26 open-chest dogs (12 with intact circulatory reflexes and 14 areflex dogs)
Measurement of venous return at various right atrial pressures
Venous return curve (relationship between venous return and right atrial pressure)surrogate
This foundational physiological study demonstrates that venous return plateaus at negative right atrial pressures and falls to zero when right atrial pressure equals mean circulatory pressure.
The normal venous return curve has been determined in 12 open-chest dogs with intact circulatory reflexes and in 14 open-chest areflex dogs. These curves show that venous return reaches a maximum value when the right atrial pressure falls to –2 to –4 mm Hg and remains at this maximum value down to infinitely low negative pressures. As the right atrial pressure rises to positive values venous return falls and reaches zero when the right atrial pressure has risen to equal the mean circulatory pressure. A venous return curve for the normal, intact dog has been tentatively formulated on the basis of these studies and previous studies in which individual points on the venous return curves of intact dogs have been measured.
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Arthur C. Guyton
Emory University
A. W. Lindsey
Denison University
Berry Abernathy
University Medical Center
American Journal of Physiology-Legacy Content
University of Mississippi
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Guyton et al. (Sat,) studied this question.
synapsesocial.com/papers/69d56f7275589c71d767d8a0 — DOI: https://doi.org/10.1152/ajplegacy.1957.189.3.609