July 23, 2015Open Access

Influence of beta-blockers on endothelial function: A meta-analysis of randomized controlled trials

Structured PICO

Do beta-blockers improve endothelial function compared to placebo or other antihypertensive agents?

Population

Patients in randomized controlled trials evaluating beta-blockers

Intervention

Beta-blockers (including second and third generation)

Comparator

Placebo, angiotensin receptor blockers (ARB), calcium channel blockers (CCB), diuretics, or angiotensin-converting enzyme inhibitors (ACEI)

Outcome

Endothelial function (including flow-mediated dilation [FMD] values)surrogate

Beta-blockers, particularly third-generation agents, improve endothelial function compared to placebo, though their benefit is less than that of ACE inhibitors.

Abstract

Beta-blockers improve the endothelial function compared with placebo. More-over, third generation beta-blockers improve FMD values significantly better than the second generation ones. Beta-blockers had similar effect on endothelial function as did ARB, CCB or diuretics. However, the beneficial effect of beta-blockers was lower when confronted with ACEI.

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Cite This Study

Peller et al. (Thu,) studied this question.

synapsesocial.com/papers/69d570e975589c71d767e00c https://doi.org/https://doi.org/10.5603/cj.a2015.0042

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