January 1, 2013Open Access

Role of Tumor Necrosis Factor-α in the Pathogenesis of Atrial Fibrosis and Development of an Arrhythmogenic Substrate

Structured PICO

P

Population

mice

I

Intervention

Tumor Necrosis Factor-α (TNF-α) pathway evaluation

O

Outcome

Pathogenesis of atrial fibrosis, altered connexin-40 expression, and development of an arrhythmogenic substratesurrogate

TNF-α contributes to the development of an arrhythmogenic substrate and atrial fibrillation in mice through TGF-β signaling, myofibroblast activation, and MMP secretion.

Abstract

TNF-α is involved in the pathogenesis of atrial fibrosis and altered connexin-40 expression in mice through the TGF-β signaling pathway, activation of myofibroblasts and increased secretion of MMPs. Collectively, these changes may contribute to the arrhythmogenic substrate and development of AF.

Role of Tumor Necrosis Factor-α in the Pathogenesis of Atrial Fibrosis and Development of an Arrhythmogenic Substrate

Structured PICO

Abstract

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Also Consider