Optimizing Tacrolimus Target Trough Levels in Organ Transplantation Among Patients Living With HIV Receiving Antiretroviral Therapy

Key Points

• To explore the importance of optimizing tacrolimus exposure in organ transplantation for patients living with HIV.
• Examined tacrolimus dosing considering antiretroviral therapy (ART) effects.
• Utilized therapeutic drug monitoring (TDM) strategies.
• Assessed variability in drug exposure and graft outcomes.
• Found that optimizing tacrolimus levels improves transplant outcomes.
• Reduced variability in drug exposure associated with integrating ART-informed dosing.