Objectives: This study sought to determine the radiological factors associated with early neurologic deterioration (END) and long-term functional outcomes (LFO) in acute ischemic stroke (AIS) patients following thrombolysis treatment. Methods: We retrospectively included patients with symptomatic anterior circulation large vessel stenosis or occlusion stroke. The National Institutes of Health Stroke Scale (NIHSS) was used to measure the severity of the symptoms both at admission and 72 hours later. We used a binary logistic regression model to identify the functional independence image factors. Results: There was a substantial correlation between the occurrence of END and unfavorable scores on the mRS at 90 days. The significant CT parameter predictors for END and an unfavorable 90-day mRS score were lower regional leptomeningeal collateral (rLMC) score, larger volume of perfusion lesion, infarct core, and ischemic penumbra. As shown by area under the receiver operator characteristic curves (AUCs) for predicting the long-term functional outcomes, the optimal thresholds of the rLMC score, perfusion lesion, infarct core, and ischemic penumbra were 17.5, 90 mL, 14.5 mL, and 57.0 mL, respectively. Conclusions: In patients with symptomatic AIS treated with thrombolysis, CT imaging parameters, including rLMC, perfusion lesions, infarct core, and ischemic penumbra have independent predictive significance for END and LFO. Advances in Knowledge: Our findings may help to improve the understanding of the prognostic value of these factors, identify potential therapeutic targets, and guide clinical decision-making for AIS patients undergoing thrombolysis.
Li et al. (Fri,) studied this question.
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