Does pyridostigmine improve standing BP in patients with neurogenic orthostatic hypotension?
Pyridostigmine effectively improves standing blood pressure in neurogenic orthostatic hypotension without the common adverse effect of supine hypertension.
Pyridostigmine significantly improves standing BP in patients with OH without worsening supine hypertension. The greatest effect is on diastolic BP, suggesting that the improvement is due to increased total peripheral resistance.
Singer et al. (2006) studied this question.