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February 1, 2011Journal of Clinical Oncology1,626 citationsOpen Access

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

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PRPaul F. RobbinsRMRichard A. MorganSFSteven A. Feldman

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Abstract

These observations indicate that TCR-based gene therapies directed against NY-ESO-1 represent a new and effective therapeutic approach for patients with melanoma and synovial cell sarcoma. To our knowledge, this represents the first demonstration of the successful treatment of a nonmelanoma tumor using TCR-transduced T cells.

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Robbins et al. (2011) studied this question.

synapsesocial.com/papers/69d6c4f5e328128020aa8375https://doi.org/10.1200/jco.2010.32.2537
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