Key points are not available for this paper at this time.
An audacious macroaldolization is the key step in the first total synthesis of the cytotoxic epothilone A, which starts with the units 1, 2, and 3. This condensation closes the ring to form the macrolide, whose structure was determined and published (also in Angewandte Chemie) as recently as July 1996.
Balog et al. (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: