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June 25, 1999View1,710 citations

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

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CCCharles A. CzeislerJDJeanne F. DuffyTSTheresa L. Shanahan

Key Points

  • The aim is to accurately estimate the periods of human circadian rhythms and understand their stability across ages.
  • Controlled lighting conditions for both young and older individuals
  • Measurement of endogenous rhythms of melatonin, core body temperature, and cortisol
  • Analysis of circadian pacemaker period across age groups
  • The intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups.
  • The distribution of the circadian period is tight and consistent with findings in other species.
  • Age-related changes in circadian parameters are clarified in the context of disrupted sleep.

Abstract

Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.

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Cite This Study

Czeisler et al. (1999) studied this question.

synapsesocial.com/papers/69d73fd2c74376700bf3116bhttps://doi.org/10.1126/science.284.5423.2177
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