To summarize the primary mechanisms responsible for ventilator-induced lung injury and evaluate clinical methods for its prevention.
Narrative literature review synthesizing evidence on the pathophysiological mechanisms of mechanical ventilation-induced lung injury.
Evaluation of protective ventilatory strategies and therapeutic interventions aimed at mitigating pulmonary damage.
Mechanical ventilation can directly cause or exacerbate lung injury through excessive alveolar distension, high airway pressures, and repetitive alveolar collapse and reopening.
Implementation of lung-protective ventilation strategies, including reduced tidal volumes and optimized positive end-expiratory pressure, helps minimize mechanical stress and reduce tissue damage.
Abstract
Mechanical ventilation may cause injury to the ventilated lung. This article reviews the probable causes of such injury and ways to prevent it.